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By N2H

FROM THE COVER: FAST DYNAMICS OF SUPERCOILED DNA REVEALED BY SINGLE-MOLECULE EXPERIMENTS

Proceedings of a National Academy of Sciences, Vol. 104, No. twenty-nine. ( seventeen Jul 2007), pp. 11957-11962.

The dynamics of supercoiled DNA fool around an critical purpose in assorted mobile processes such as transcription as well as riposte which engage DNA supercoiling. We benefaction experiments which raise a bargain of these dynamics by measuring a unique reply of singular DNA molecules to remarkable changes in tragedy or torsion. A celebrated dynamics can be fairly described by quasistatic models, eccentric of a grade of supercoiling primarily benefaction in a molecules. In sold, a dynamics have been not influenced by a successive dismissal of a plectonemes. These formula set an top firm upon a hydrodynamic draw towards hostile plectoneme dismissal, as well as to illustrate yield a quantitative baseline for a dynamics of unclothed DNA. 10. 1073/pnas. 0700333104
Aurelien Crut, Daniel Koster, Ralf Seidel, Chris Wiggins, Nynke Dekker

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